Article-Journal

oRGs and mitotic somal translocation - a role in development and disease.

The evolution of the human brain has been characterized by an increase in the size of the neocortex. Underlying this expansion is a …

Ostrem B, Di Lullo E, Kriegstein A

Dynamic behaviour of human neuroepithelial cells in the developing forebrain.

To understand how diverse progenitor cells contribute to human neocortex development, we examined forebrain progenitor behaviour using …

Subramanian L, Bershteyn M, Paredes MF, Arnold R Kriegstein, MD, PhD

Zika virus cell tropism in the developing human brain and inhibition by azithromycin.

The rapid spread of Zika virus (ZIKV) and its association with abnormal brain development constitute a global health emergency. …

Retallack H, Di Lullo E, Arias C, Knopp KA, Laurie MT, Sandoval-Espinosa C, Mancia Leon WR, Krencik R, Ullian EM, Spatazza J, Pollen AA, Mandel-Brehm C, Nowakowski TJ, Arnold R Kriegstein, MD, PhD, DeRisi JL

Single-cell sequencing maps gene expression to mutational phylogenies in PDGF- and EGF-driven gliomas.

Glioblastoma multiforme (GBM) is the most common and aggressive type of primary brain tumor. Epidermal growth factor (EGF) and …

Muller S, Liu SJ, Di Lullo E, Malatesta M, Pollen AA, Nowakowski TJ, Kohanbash G, Aghi M, Arnold R Kriegstein, MD, PhD, Lim DA, Diaz A

Primate Neurons Flex Their Musclin.

Sensory experience evokes long-lasting changes in neural circuits through activity-dependent gene expression. Ataman et al. (2016) …

Pollen AA, Arnold R Kriegstein, MD, PhD

Transplanted Human Stem Cell-Derived Interneuron Precursors Mitigate Mouse Bladder Dysfunction and Central Neuropathic Pain after Spinal Cord Injury.

Neuropathic pain and bladder dysfunction represent significant quality-of-life issues for many spinal cord injury patients. Loss of …

Fandel TM, Trivedi A, Nicholas CR, Zhang H, Chen J, Martinez AF, Noble-Haeusslein LJ, Arnold R Kriegstein, MD, PhD

Transformation of the Radial Glia Scaffold Demarcates Two Stages of Human Cerebral Cortex Development.

The classic view of cortical development, embodied in the radial unit hypothesis, highlights the ventricular radial glia (vRG) scaffold …

Nowakowski TJ, Pollen AA, Sandoval-Espinosa C, Arnold R Kriegstein, MD, PhD

SCell: integrated analysis of single-cell RNA-seq data.

Analysis of the composition of heterogeneous tissue has been greatly enabled by recent developments in single-cell transcriptomics. We …

Diaz A, Liu SJ, Sandoval C, Pollen A, Nowakowski TJ, Lim DA, Kriegstein A

A Primate lncRNA Mediates Notch Signaling during Neuronal Development by Sequestering miRNA.

Long non-coding RNAs (lncRNAs) are a diverse and poorly conserved category of transcripts that have expanded greatly in primates, …

Rani N, Nowakowski TJ, Zhou H, Godshalk SE, Lisi V, Arnold R Kriegstein, MD, PhD, Kosik KS

Expression Analysis Highlights AXL as a Candidate Zika Virus Entry Receptor in Neural Stem Cells.

The recent outbreak of Zika virus (ZIKV) in Brazil has been linked to substantial increases in fetal abnormalities and microcephaly. …

Nowakowski TJ, Pollen AA, Di Lullo E, Sandoval-Espinosa C, Bershteyn M, Arnold R Kriegstein, MD, PhD