Article-Journal

Secretagogin is Expressed by Developing Neocortical GABAergic Neurons in Humans but not Mice and Increases Neurite Arbor Size and Complexity.
The neocortex of primates, including humans, contains more abundant and diverse inhibitory neurons compared with rodents, but the …
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Human-Specific NOTCH2NL Genes Affect Notch Signaling and Cortical Neurogenesis.
Genetic changes causing brain size expansion in human evolution have remained elusive. Notch signaling is essential for radial glia …
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An analytical framework for whole-genome sequence association studies and its implications for autism spectrum disorder.
Genomic association studies of common or rare protein-coding variation have established robust statistical approaches to account for …
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Human hippocampal neurogenesis drops sharply in children to undetectable levels in adults.
New neurons continue to be generated in the subgranular zone of the dentate gyrus of the adult mammalian hippocampus. This process has …
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Single-cell profiling of human gliomas reveals macrophage ontogeny as a basis for regional differences in macrophage activation in the tumor microenvironment.
BACKGROUND: Tumor-associated macrophages (TAMs) are abundant in gliomas and immunosuppressive TAMs are a barrier to emerging …
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Spatiotemporal gene expression trajectories reveal developmental hierarchies of the human cortex.
Systematic analyses of spatiotemporal gene expression trajectories during organogenesis have been challenging because diverse cell …
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The Human Cell Atlas.
The recent advent of methods for high-throughput single-cell molecular profiling has catalyzed a growing sense in the scientific …
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The BRAIN Initiative Cell Census Consortium: Lessons Learned toward Generating a Comprehensive Brain Cell Atlas.
A comprehensive characterization of neuronal cell types, their distributions, and patterns of connectivity is critical for …
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The use of brain organoids to investigate neural development and disease.
Understanding the development and dysfunction of the human brain is a major goal of neurobiology. Much of our current understanding of …
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Human iPSC-Derived Cerebral Organoids Model Cellular Features of Lissencephaly and Reveal Prolonged Mitosis of Outer Radial Glia.
Classical lissencephaly is a genetic neurological disorder associated with mental retardation and intractable epilepsy, and …
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