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Identification of amygdala-expressed genes associated with autism spectrum disorder.
BACKGROUND: Studies of individuals with autism spectrum disorder (ASD) have revealed a strong multigenic basis with the identification …
Herrero MJ
,
Velmeshev D
,
Hernandez-Pineda D
,
Sethi S
,
Sorrells S
,
Banerjee P
,
Sullivan C
,
Gupta AR
,
Arnold R Kriegstein, MD, PhD
,
Corbin JG
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DOI
Medulloblastoma Arises from the Persistence of a Rare and Transient Sox2(+) Granule Neuron Precursor.
Medulloblastoma (MB) is a neoplasm linked to dysregulated cerebellar development. Previously, we demonstrated that the Sonic Hedgehog …
Selvadurai HJ
,
Luis E
,
Desai K
,
Lan X
,
Vladoiu MC
,
Whitley O
,
Galvin C
,
Vanner RJ
,
Lee L
,
Whetstone H
,
Kushida M
,
Nowakowski T
,
Diamandis P
,
Hawkins C
,
Bader G
,
Kriegstein A
,
Taylor MD
,
Dirks PB
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DOI
Cortical Neural Stem Cell Lineage Progression Is Regulated by Extrinsic Signaling Molecule Sonic Hedgehog.
Neural stem cells (NSCs) in the prenatal neocortex progressively generate different subtypes of glutamatergic projection neurons. …
Zhang Y
,
Liu G
,
Guo T
,
Liang XG
,
Du H
,
Yang L
,
Bhaduri A
,
Li X
,
Xu Z
,
Zhang Z
,
Li Z
,
He M
,
Tsyporin J
,
Arnold R Kriegstein, MD, PhD
,
Rubenstein JL
,
Yang Z
,
Chen B
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DOI
Cell stress in cortical organoids impairs molecular subtype specification.
Cortical organoids are self-organizing three-dimensional cultures that model features of the developing human cerebral cortex(1,2). …
Bhaduri A
,
Andrews MG
,
Mancia Leon W
,
Shin D
,
Allen D
,
Jung D
,
Schmunk G
,
Haeussler M
,
Salma J
,
Pollen AA
,
Nowakowski TJ
,
Arnold R Kriegstein, MD, PhD
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DOI
Outer Radial Glia-like Cancer Stem Cells Contribute to Heterogeneity of Glioblastoma.
Glioblastoma is a devastating form of brain cancer. To identify aspects of tumor heterogeneity that may illuminate drivers of tumor …
Bhaduri A
,
Di Lullo E
,
Jung D
,
Muller S
,
Crouch EE
,
Espinosa CS
,
Ozawa T
,
Alvarado B
,
Spatazza J
,
Cadwell CR
,
Wilkins G
,
Velmeshev D
,
Liu SJ
,
Malatesta M
,
Andrews MG
,
Mostajo-Radji MA
,
Huang EJ
,
Nowakowski TJ
,
Lim DA
,
Diaz A
,
Raleigh DR
,
Arnold R Kriegstein, MD, PhD
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DOI
SMART-Q: An Integrative Pipeline Quantifying Cell Type-Specific RNA Transcription.
Accurate RNA quantification at the single-cell level is critical for understanding the dynamics of gene expression and regulation …
Yang X
,
Bergenholtz S
,
Maliskova L
,
Pebworth MP
,
Arnold R Kriegstein, MD, PhD
,
Li Y
,
Shen Y
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DOI
Neuroglial stem cell-derived inflammatory pseudotumor (n-SCIPT): clinicopathologic characterization of a novel lesion of the lumbosacral spinal cord and nerve roots following intrathecal allogeneic stem cell intervention.
PubMed ID:
31659431
Sloan EA
,
Sampognaro PJ
,
Junn JC
,
Chin C
,
Jacques L
,
Ramachandran PS
,
DeRisi JL
,
Wilson MR
,
Arnold R Kriegstein, MD, PhD
,
Bollen AW
,
Solomon DA
,
Margeta M
,
Engstrom JW
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DOI
The Phenotypes of Proliferating Glioblastoma Cells Reside on a Single Axis of Variation.
Although tumor-propagating cells can be derived from glioblastomas (GBM) of the proneural and mesenchymal subtypes, a glioma stem-like …
Li Wang, PhD
,
Babikir H
,
Muller S
,
Yagnik G
,
Shamardani K
,
Catalan F
,
Kohanbash G
,
Alvarado B
,
Di Lullo E
,
Kriegstein A
,
Shah S
,
Wadhwa H
,
Chang SM
,
Phillips JJ
,
Aghi MK
,
Diaz AA
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DOI
Oligodendrocyte Death in Pelizaeus-Merzbacher Disease Is Rescued by Iron Chelation.
Pelizaeus-Merzbacher disease (PMD) is an X-linked leukodystrophy caused by mutations in Proteolipid Protein 1 (PLP1), encoding a major …
Nobuta H
,
Yang N
,
Ng YH
,
Marro SG
,
Sabeur K
,
Chavali M
,
Stockley JH
,
Killilea DW
,
Walter PB
,
Zhao C
,
Huie P Jr
,
Goldman SA
,
Arnold R Kriegstein, MD, PhD
,
Franklin RJM
,
Rowitch DH
,
Wernig M
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DOI
Neuronal vulnerability and multilineage diversity in multiple sclerosis.
Multiple sclerosis (MS) is a neuroinflammatory disease with a relapsing-remitting disease course at early stages, distinct lesion …
Schirmer L
,
Velmeshev D
,
Holmqvist S
,
Kaufmann M
,
Werneburg S
,
Jung D
,
Vistnes S
,
Stockley JH
,
Young A
,
Steindel M
,
Tung B
,
Goyal N
,
Bhaduri A
,
Mayer S
,
Engler JB
,
Bayraktar OA
,
Franklin RJM
,
Haeussler M
,
Reynolds R
,
Schafer DP
,
Friese MA
,
Shiow LR
,
Arnold R Kriegstein, MD, PhD
,
Rowitch DH
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DOI
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