Article-Journal

Human intermediate progenitor diversity during cortical development.
Studies of the spatiotemporal, transcriptomic, and morphological diversity of radial glia (RG) have spurred our current models of human …
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Single-cell atlas of early human brain development highlights heterogeneity of human neuroepithelial cells and early radial glia.
The human cortex comprises diverse cell types that emerge from an initially uniform neuroepithelium that gives rise to radial glia, the …
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Neurotoxic microglia promote TDP-43 proteinopathy in progranulin deficiency.
Aberrant aggregation of the RNA-binding protein TDP-43 in neurons is a hallmark of frontotemporal lobar degeneration caused by …
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Cell-type-specific 3D epigenomes in the developing human cortex.
Lineage-specific epigenomic changes during human corticogenesis have been difficult to study owing to challenges with sample …
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Mitochondria Control Cortical Cell Fate after Mitosis.
During brain development, the daughter cells of neural stem cells have to make a choice - either to become new stem cells or to …
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Single-Cell Analyses Identify Brain Mural Cells Expressing CD19 as Potential Off-Tumor Targets for CAR-T Immunotherapies.
CD19-directed immunotherapies are clinically effective for treating B cell malignancies but also cause a high incidence of …
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Are Organoids Ready for Prime Time?
Innovations in organoid-based models of human tissues have made them an exciting experimental platform for studying development and …
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mTOR signaling regulates the morphology and migration of outer radial glia in developing human cortex.
Outer radial glial (oRG) cells are a population of neural stem cells prevalent in the developing human cortex that contribute to its …
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A Chromatin Accessibility Atlas of the Developing Human Telencephalon.
To discover regulatory elements driving the specificity of gene expression in different cell types and regions of the developing human …
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Origins and Proliferative States of Human Oligodendrocyte Precursor Cells.
Human cerebral cortex size and complexity has increased greatly during evolution. While increased progenitor diversity and enhanced …
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