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Tropism of SARS-CoV-2 for human cortical astrocytes.
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) readily infects a variety of cell types impacting the function of …
Andrews MG
,
Tanzila Mukhtar, PhD
,
Eze UC
,
Simoneau CR
,
Ross J
,
Parikshak N
,
Shaohui Wang
,
Li Zhou, PhD
,
Koontz M
,
Velmeshev D
,
Siebert CV
,
Gemenes KM
,
Tabata T
,
Yonatan Perez, PhD
,
Li Wang, PhD
,
Mostajo-Radji MA
,
De Majo M
,
Donohue KC
,
Shin D
,
Salma J
,
Pollen AA
,
Nowakowski TJ
,
Ullian E
,
Kumar GR
,
Winkler EA
,
Crouch EE
,
Ott M
,
Arnold R Kriegstein, MD, PhD
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DOI
Challenges of Organoid Research.
Organoids are 3D cell culture systems derived from human pluripotent stem cells that contain tissue resident cell types and reflect …
Andrews MG
,
Arnold R Kriegstein, MD, PhD
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DOI
Molecular profiling of stem cell-derived retinal pigment epithelial cell differentiation established for clinical translation.
Human embryonic stem cell-derived retinal pigment epithelial cells (hESC-RPE) are a promising cell source to treat age-related macular …
Petrus-Reurer S
,
Lederer AR
,
Baque-Vidal L
,
Douagi I
,
Pannagel B
,
Khven I
,
Aronsson M
,
Bartuma H
,
Wagner M
,
Wrona A
,
Efstathopoulos P
,
Jaberi E
,
Willenbrock H
,
Shimizu Y
,
Villaescusa JC
,
Andre H
,
Sundstrӧm E
,
Bhaduri A
,
Kriegstein A
,
Kvanta A
,
La Manno G
,
Lanner F
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DOI
Diversifying stem cell debates: Including Muslim contexts and perspectives.
Greater transcultural and transdisciplinary engagement within Muslim contexts and deliberate inclusion of diverse Muslim voices in the …
Dajani R
,
Jiwani B
,
Nanji A
,
Zoloth L
,
Ghaly M
,
Ilkilic I
,
Raya A
,
Patrao Neves M
,
De Melo H
,
Carvalho AS
,
Caulfield T
,
Carter R
,
Rendas A
,
Surani A
,
Rossant J
,
Kriegstein A
,
Lalani EN
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DOI
Nests of dividing neuroblasts sustain interneuron production for the developing human brain.
The human cortex contains inhibitory interneurons derived from the medial ganglionic eminence (MGE), a germinal zone in the embryonic …
Paredes MF
,
Mora C
,
Flores-Ramirez Q
,
Cebrian-Silla A
,
Del Dosso A
,
Larimer P
,
Chen J
,
Kang G
,
Gonzalez-Granero S
,
Garcia E
,
Chu J
,
Delgado R
,
Cotter JA
,
Tang V
,
Spatazza J
,
Obernier K
,
Ferrer Lozano J
,
Vento M
,
Scott J
,
Studholme C
,
Nowakowski TJ
,
Arnold R Kriegstein, MD, PhD
,
Oldham MC
,
Hasenstaub A
,
Garcia-Verdugo JM
,
Alvarez-Buylla A
,
Huang EJ
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DOI
Identification of Lipid Heterogeneity and Diversity in the Developing Human Brain.
The lipidome is currently understudied but fundamental to life. Within the brain, little is known about cell-type lipid heterogeneity, …
Bhaduri A
,
Neumann EK
,
Arnold R Kriegstein, MD, PhD
,
Sweedler JV
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DOI
Phospholipid-flippase chaperone CDC50A is required for synapse maintenance by regulating phosphatidylserine exposure.
Synaptic refinement is a critical physiological process that removes excess synapses to establish and maintain functional neuronal …
Li T
,
Yu D
,
Oak HC
,
Zhu B
,
Li Wang, PhD
,
Jiang X
,
Molday RS
,
Kriegstein A
,
Piao X
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DOI
An atlas of cortical arealization identifies dynamic molecular signatures.
The human brain is subdivided into distinct anatomical structures, including the neocortex, which in turn encompasses dozens of …
Bhaduri A
,
Sandoval-Espinosa C
,
Otero-Garcia M
,
Oh I
,
Yin R
,
Eze UC
,
Nowakowski TJ
,
Arnold R Kriegstein, MD, PhD
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DOI
A roadmap for the Human Developmental Cell Atlas.
The Human Developmental Cell Atlas (HDCA) initiative, which is part of the Human Cell Atlas, aims to create a comprehensive reference …
Haniffa M
,
Taylor D
,
Linnarsson S
,
Aronow BJ
,
Bader GD
,
Barker RA
,
Camara PG
,
Camp JG
,
Chedotal A
,
Copp A
,
Etchevers HC
,
Giacobini P
,
Gottgens B
,
Guo G
,
Hupalowska A
,
James KR
,
Kirby E
,
Kriegstein A
,
Lundeberg J
,
Marioni JC
,
Meyer KB
,
Niakan KK
,
Nilsson M
,
Olabi B
,
Pe'er D
,
Regev A
,
Rood J
,
Rozenblatt-Rosen O
,
Satija R
,
Teichmann SA
,
Treutlein B
,
Vento-Tormo R
,
Webb S
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DOI
Distinct nuclear compartment-associated genome architecture in the developing mammalian brain.
Nuclear compartments are thought to play a role in three-dimensional genome organization and gene expression. In mammalian brain, the …
Ahanger SH
,
Delgado RN
,
Gil E
,
Cole MA
,
Zhao J
,
Hong SJ
,
Arnold R Kriegstein, MD, PhD
,
Nowakowski TJ
,
Pollen AA
,
Lim DA
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DOI
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