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A cross-species proteomic map reveals neoteny of human synapse development.
The molecular mechanisms and evolutionary changes accompanying synapse development are still poorly understood(1,2). Here we generate a …
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Osteopontin drives retinal ganglion cell resiliency in glaucomatous optic neuropathy.
Chronic neurodegeneration and acute injuries lead to neuron losses via diverse processes. We compared retinal ganglion cell (RGC) …
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Astroglial toxicity promotes synaptic degeneration in the thalamocortical circuit in frontotemporal dementia with GRN mutations.
Mutations in the human progranulin (GRN) gene are a leading cause of frontotemporal lobar degeneration (FTLD). While previous studies …
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Machine learning dissection of human accelerated regions in primate neurodevelopment.
Using machine learning (ML), we interrogated the function of all human-chimpanzee variants in 2,645 human accelerated regions (HARs), …
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Non-muscle myosins control the integrity of cortical radial glial endfeet.
Radial glial cells, the stem cells of the cerebral cortex, extend a long basal fiber that ends in basal endfeet. A new study in PLOS …
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ACVR1-activating mutation causes neuropathic pain and sensory neuron hyperexcitability in humans.
Altered bone morphogenetic protein (BMP) signaling is associated with many musculoskeletal diseases. However, it remains unknown …
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How mechanisms of stem cell polarity shape the human cerebral cortex.
Apical-basal progenitor cell polarity establishes key features of the radial and laminar architecture of the developing human cortex. …
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Ensembles of endothelial and mural cells promote angiogenesis in prenatal human brain.
Interactions between angiogenesis and neurogenesis regulate embryonic brain development. However, a comprehensive understanding of the …
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Zika virus alters centrosome organization to suppress the innate immune response.
Zika virus (ZIKV) is a flavivirus transmitted via mosquitoes and sex to cause congenital neurodevelopmental defects, including …
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A nomenclature consensus for nervous system organoids and assembloids.
Self-organizing three-dimensional cellular models derived from human pluripotent stem cells or primary tissue have great potential to …
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