Article-Journal

A framework for neural organoids, assembloids and transplantation studies.
As the field of neural organoids and assembloids expands, there is an emergent need for guidance and advice on designing, conducting …
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The commitment of the human cell atlas to humanity.
The Human Cell Atlas (HCA) is a global partnership “to create comprehensive reference maps of all human cells-the fundamental …
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Proinflammatory immune cells disrupt angiogenesis and promote germinal matrix hemorrhage in prenatal human brain.
Germinal matrix hemorrhage (GMH) is a devastating neurodevelopmental condition affecting preterm infants, but why blood vessels in this …
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Perivascular neurons instruct 3D vascular lattice formation via neurovascular contact.
The vasculature of the central nervous system is a 3D lattice composed of laminar vascular beds interconnected by penetrating vessels. …
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A conserved molecular logic for neurogenesis to gliogenesis switch in the cerebral cortex.
During development, neural stem cells in the cerebral cortex, also known as radial glial cells (RGCs), generate excitatory neurons, …
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Protracted neuronal recruitment in the temporal lobes of young children.
The temporal lobe of the human brain contains the entorhinal cortex (EC). This region of the brain is a highly interconnected …
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Single-cell genomics reveals region-specific developmental trajectories underlying neuronal diversity in the human hypothalamus.
The development and diversity of neuronal subtypes in the human hypothalamus has been insufficiently characterized. To address this, we …
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Single-cell analysis of prenatal and postnatal human cortical development.
We analyzed >700,000 single-nucleus RNA sequencing profiles from 106 donors during prenatal and postnatal developmental stages and …
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Human pallial MGE-type GABAergic interneuron cell therapy for chronic focal epilepsy.
Mesial temporal lobe epilepsy (MTLE) is the most common focal epilepsy. One-third of patients have drug-refractory seizures and are …
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LIF signaling regulates outer radial glial to interneuron fate during human cortical development.
Radial glial (RG) development is essential for cerebral cortex growth and organization. In humans, the outer radial glia (oRG) subtype …
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