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Orienting fate: spatial regulation of neurogenic divisions.
Cleavage plane orientation has been thought to govern the fate of neural stem cell progeny, but supporting evidence in the neocortex …
Wang X
,
Lui JH
,
Arnold R Kriegstein, MD, PhD
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DOI
Persistent sonic hedgehog signaling in adult brain determines neural stem cell positional identity.
Neural stem cells (NSCs) persist in the subventricular zone (SVZ) of the adult brain. Location within this germinal region determines …
Ihrie RA
,
Shah JK
,
Harwell CC
,
Levine JH
,
Guinto CD
,
Lezameta M
,
Arnold R Kriegstein, MD, PhD
,
Alvarez-Buylla A
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DOI
Development and evolution of the human neocortex.
The size and surface area of the mammalian brain are thought to be critical determinants of intellectual ability. Recent studies show …
Lui JH
,
Hansen DV
,
Arnold R Kriegstein, MD, PhD
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DOI
Deriving excitatory neurons of the neocortex from pluripotent stem cells.
The human cerebral cortex is an immensely complex structure that subserves critical functions that can be disrupted in developmental …
Hansen DV
,
Rubenstein JL
,
Arnold R Kriegstein, MD, PhD
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DOI
A new subtype of progenitor cell in the mouse embryonic neocortex.
A hallmark of mammalian brain evolution is cortical expansion, which reflects an increase in the number of cortical neurons established …
Wang X
,
Tsai JW
,
LaMonica B
,
Arnold R Kriegstein, MD, PhD
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DOI
Blocking early GABA depolarization with bumetanide results in permanent alterations in cortical circuits and sensorimotor gating deficits.
A high incidence of seizures occurs during the neonatal period when immature networks are hyperexcitable and susceptible to …
Wang DD
,
Arnold R Kriegstein, MD, PhD
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DOI
Kinesin 3 and cytoplasmic dynein mediate interkinetic nuclear migration in neural stem cells.
Radial glial progenitor cells exhibit bidirectional cell cycle-dependent nuclear oscillations. The purpose and underlying mechanism of …
Tsai JW
,
Lian WN
,
Kemal S
,
Arnold R Kriegstein, MD, PhD
,
Vallee RB
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DOI
Developmental genetics of vertebrate glial-cell specification.
Oligodendrocytes and astrocytes are macroglial cells of the vertebrate central nervous system. These cells have diverse roles in the …
Rowitch DH
,
Arnold R Kriegstein, MD, PhD
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DOI
Connexin 43 mediates the tangential to radial migratory switch in ventrally derived cortical interneurons.
The adult cerebral cortex is composed of excitatory and inhibitory neurons that arise from progenitor cells in disparate proliferative …
Elias LA
,
Turmaine M
,
Parnavelas JG
,
Arnold R Kriegstein, MD, PhD
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DOI
Neurogenic radial glia in the outer subventricular zone of human neocortex.
Neurons in the developing rodent cortex are generated from radial glial cells that function as neural stem cells. These epithelial …
Hansen DV
,
Lui JH
,
Parker PR
,
Arnold R Kriegstein, MD, PhD
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DOI
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