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Functional maturation of hPSC-derived forebrain interneurons requires an extended timeline and mimics human neural development.
Directed differentiation from human pluripotent stem cells (hPSCs) has seen significant progress in recent years. However, most …
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A high-resolution enhancer atlas of the developing telencephalon.
The mammalian telencephalon plays critical roles in cognition, motor function, and emotion. Though many of the genes required for its …
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Regulation of microtubule stability and organization by mammalian Par3 in specifying neuronal polarity.
Polarization of mammalian neurons with a specified axon requires precise regulation of microtubule and actin dynamics in the developing …
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Mitotic spindle orientation predicts outer radial glial cell generation in human neocortex.
The human neocortex is increased in size and complexity as compared with most other species. Neocortical expansion has recently been …
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Use of "MGE enhancers" for labeling and selection of embryonic stem cell-derived medial ganglionic eminence (MGE) progenitors and neurons.
The medial ganglionic eminence (MGE) is an embryonic forebrain structure that generates the majority of cortical interneurons. MGE …
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SnapShot: cortical development.

PubMed ID: 23141546

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Stem cells in the land of the rising sun: ISSCR 2012.
The 2012 annual meeting of the International Society for Stem Cell Research (ISSCR) marked the Tenth Anniversary of the ISSCR. Held in …
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OSVZ progenitors in the human cortex: an updated perspective on neurodevelopmental disease.
Recent discoveries concerning the architecture and cellular dynamics of the developing human brain are revealing new differences …
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Forebrain GABAergic neuron precursors integrate into adult spinal cord and reduce injury-induced neuropathic pain.
Neuropathic pain is a chronic debilitating disease characterized by mechanical allodynia and spontaneous pain. Because symptoms are …
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Sonic hedgehog expression in corticofugal projection neurons directs cortical microcircuit formation.
The precise connectivity of inputs and outputs is critical for cerebral cortex function; however, the cellular mechanisms that …
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