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Single-cell analysis of long non-coding RNAs in the developing human neocortex.
BACKGROUND: Long non-coding RNAs (lncRNAs) comprise a diverse class of transcripts that can regulate molecular and cellular processes …
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A GABAergic projection from the zona incerta to cortex promotes cortical neuron development.
gamma-Aminobutyric acid (GABA) is the major inhibitory transmitter in the mature brain but is excitatory in the developing cortex. We …
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Neuronal Migration Dynamics in the Developing Ferret Cortex.
During mammalian neocortical development, newborn excitatory and inhibitory neurons must migrate over long distances to reach their …
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Molecular identity of human outer radial glia during cortical development.
Radial glia, the neural stem cells of the neocortex, are located in two niches: the ventricular zone and outer subventricular zone. …
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Wide Dispersion and Diversity of Clonally Related Inhibitory Interneurons.
The mammalian neocortex is composed of two major neuronal cell types with distinct origins: excitatory pyramidal neurons and inhibitory …
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The long noncoding RNA Pnky regulates neuronal differentiation of embryonic and postnatal neural stem cells.
While thousands of long noncoding RNAs (lncRNAs) have been identified, few lncRNAs that control neural stem cell (NSC) behavior are …
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Radial glia require PDGFD-PDGFRbeta signalling in human but not mouse neocortex.
Evolutionary expansion of the human neocortex underlies many of our unique mental abilities. This expansion has been attributed to the …
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Low-coverage single-cell mRNA sequencing reveals cellular heterogeneity and activated signaling pathways in developing cerebral cortex.
Large-scale surveys of single-cell gene expression have the potential to reveal rare cell populations and lineage relationships but …
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Yoshiki Sasai (1962-2014).

PubMed ID: 25364807

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The Ink4a/Arf locus is a barrier to direct neuronal transdifferentiation.
Non-neurogenic cell types, such as cortical astroglia and fibroblasts, can be directly converted into neurons by the overexpression of …
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