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G-protein-coupled receptor ADGRG1 drives a protective microglial state in Alzheimer's disease through MYC activation.
PubMed ID:
41175871
Zhu B
,
Wangzhou A
,
Yu D
,
Li T
,
Schmidt R
,
De Florencio SL
,
Chao L
,
Thurber AL
,
Zhou M
,
Msheik Z
,
Yonatan Perez, PhD
,
Grinberg LT
,
Spina S
,
Ransohoff RM
,
Arnold R Kriegstein, MD, PhD
,
Seeley WW
,
Nowakowski T
,
Piao X
Cite
DOI
The need for a global effort to attend to human neural organoid and assembloid research.
A continuing international process is needed to monitor and advise this rapidly progressing field.
Pasca SP
,
Arlotta P
,
Campbell P
,
Charo A
,
Evans JH
,
Farahany N
,
Gage FH
,
Godfrey-Smith P
,
Hyun I
,
Arnold R Kriegstein, MD, PhD
,
Melloni L
,
Ming GL
,
Moreno JD
,
Sugarman J
,
Temple S
,
Testa G
,
Greely HT
Cite
DOI
Molecular and cellular dynamics of the developing human neocortex.
The development of the human neocortex is highly dynamic, involving complex cellular trajectories controlled by gene regulation(1). …
Li Wang, PhD
,
Wang C
,
Juan Moriano, PhD
,
Songcang Chen, MD
,
Guolong Zuo, PhD
,
Cebrian-Silla A
,
Zhang S
,
Tanzila Mukhtar, PhD
,
Shaohui Wang
,
Mengyi Song, PhD
,
Lilian Gomes de Oliveira, PhD
,
Quili Bi
,
Jonathan Augustin, PhD
,
Ge X
,
Paredes MF
,
Huang EJ
,
Alvarez-Buylla A
,
Duan X
,
Li J
,
Arnold R Kriegstein, MD, PhD
Cite
DOI
Spatial dynamics of brain development and neuroinflammation.
The ability to spatially map multiple layers of omics information across developmental timepoints enables exploration of the mechanisms …
Zhang D
,
Rubio Rodriguez-Kirby LA
,
Lin Y
,
Wang W
,
Mengyi Song, PhD
,
Li Wang, PhD
,
Kanatani S
,
Jimenez-Beristain T
,
Dang Y
,
Zhong M
,
Kukanja P
,
Bao S
,
Shaohui Wang
,
Chen XL
,
Gao F
,
Wang D
,
Xu H
,
Ma C
,
Lou X
,
Liu Y
,
Chen J
,
Sestan N
,
Uhlen P
,
Kriegstein A
,
Zhao H
,
Castelo-Branco G
,
Fan R
Cite
DOI
The new frontier in understanding human and mammalian brain development.
Neurodevelopmental disorders that cause cognitive, behavioural or motor impairments affect around 15% of children and adolescents …
Nowakowski TJ
,
Nano PR
,
Matho KS
,
Chen X
,
Corrigan EK
,
Ding W
,
Gao Y
,
Heffel M
,
Jayakumar J
,
Kaplan HS
,
Kronman FN
,
Kovner R
,
Mannens CCA
,
Mengyi Song, PhD
,
Steyert MR
,
Venkatesan S
,
Wallace JL
,
Li Wang, PhD
,
Werner JM
,
Zhang D
,
Yuan G
,
Guolong Zuo, PhD
,
Ament SA
,
Colantuoni C
,
Dulac C
,
Fan R
,
Gillis J
,
Arnold R Kriegstein, MD, PhD
,
Krienen FM
,
Kim Y
,
Linnarsson S
,
Mitra PP
,
Pollen AA
,
Sestan N
,
Tward DJ
,
Van Velthoven CTJ
,
Yao Z
,
Bhaduri A
,
Zeng H
Cite
DOI
Molecular and spatial analysis of ganglion cells on retinal flatmounts identifies perivascular neurons resilient to glaucoma.
Recent transcriptomic studies have categorized mouse retinal ganglion cells (RGCs) into 45 types; however, little is known about their …
Nimkar K
,
Tsai NY
,
Zhao M
,
Yi Y
,
Lum MR
,
Garrett TR
,
Wang Y
,
Toma K
,
Caval-Holme F
,
Reddy N
,
Ehrlich AT
,
Arnold R Kriegstein, MD, PhD
,
Do MTH
,
Hu Y
,
Sivyer B
,
Shekhar K
,
Duan X
Cite
DOI
G-protein-coupled receptor ADGRG1 drives a protective microglial state in Alzheimer's disease through MYC activation.
Germline genetic architecture of Alzheimer’s disease (AD) indicates microglial mechanisms of disease susceptibility and outcomes. …
Zhu B
,
Wangzhou A
,
Yu D
,
Li T
,
Schmidt R
,
De Florencio SL
,
Chao L
,
Thurber AL
,
Zhou M
,
Msheik Z
,
Yonatan Perez, PhD
,
Grinberg LT
,
Spina S
,
Ransohoff RM
,
Arnold R Kriegstein, MD, PhD
,
Seeley WW
,
Nowakowski T
,
Piao X
Cite
DOI
Single-cell analysis of dup15q syndrome reveals developmental and postnatal molecular changes in autism.
Duplication 15q (dup15q) syndrome is a leading genetic cause of autism spectrum disorder, offering a key model for studying …
Yonatan Perez, PhD
,
Velmeshev D
,
Li Wang, PhD
,
White ML
,
Clara Siebert
,
Jennifer Baltazar
,
Guolong Zuo, PhD
,
Juan Moriano, PhD
,
Songcang Chen, MD
,
Steffen DM
,
Dutton NG
,
Shaohui Wang
,
Wick B
,
Haeussler M
,
Chamberlain S
,
Alvarez-Buylla A
,
Kriegstein A
Cite
DOI
alpha7 nicotinic acetylcholine receptors regulate radial glia fate in the developing human cortex.
Prenatal nicotine exposure impairs fetal cortical grey matter volume, but the precise cellular mechanisms remain poorly understood. …
Tanzila Mukhtar, PhD
,
Siebert CV
,
Wang Y
,
Pebworth MP
,
White ML
,
Wu T
,
Huang TI
,
Guolong Zuo, PhD
,
Ross J
,
Jennifer Baltazar
,
Upadhyay V
,
Shankar M
,
Li Zhou, PhD
,
Lombardi-Coronel I
,
Mandala I
,
Adam MA
,
Shaohui Wang
,
Quili Bi
,
Hoekman MFM
,
Li J
,
Arnold R Kriegstein, MD, PhD
Cite
DOI
Fate plasticity of interneuron specification.
Neuronal subtype generation in the mammalian central nervous system is governed by competing genetic programs. The medial ganglionic …
Mostajo-Radji MA
,
Leon WRM
,
Breevoort A
,
Gonzalez-Ferrer J
,
Schweiger HE
,
Lehrer J
,
Li Zhou, PhD
,
Schmitz MT
,
Yonatan Perez, PhD
,
Tanzila Mukhtar, PhD
,
Robbins A
,
Chu J
,
Andrews MG
,
Sullivan FN
,
Tejera D
,
Choy EC
,
Paredes MF
,
Teodorescu M
,
Arnold R Kriegstein, MD, PhD
,
Alvarez-Buylla A
,
Pollen AA
Cite
DOI
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